Considering the positive effects of steranes and sterane-like molecules on HD pathology in various HD models [14,16,28,29,38,39,117,118,119,120], particularly the cholesterol (and phospholipid) transporters ABCA1 (and potentially its functional compensatory counterpart ABCA7 [164,165]) gain relevance in the pathogenesis of HD and potential therapeutic and diagnostic interventions, which warrants further investigations. This evidence concerns the gene ABCA7 and Huntington disease.