Accumulating studies proved that the nod-like receptor protein 3 (NLRP3) inflammasome is linked to activated microglia-induced inflammatory response in PD, upon α-syn stimulation, NLRP3 complex trigger caspase-1 activation and caspase-1-dependent release of IL-1β and IL-18 [250,251,252]. Here, NLRP3 is linked to Parkinson disease.