In CRC cell lines, NLGN1 upregulates mesenchymal markers and WNT target genes, enhances APC (adenomatous polyposis coli, a CRC tumor suppressor that is mutated in up to 80% of CRC samples) localization to the cell membrane, co-immunoprecipitates with some isoforms of this protein, and induces beta-catenin translocation to the nucleus. Here, APC is linked to colorectal carcinoma.