While a database study by Qian et al. [195] showed that NLGN1 is expressed in a subset of colon tumors and has negative prognostic implications, very recently we demonstrated that NLGN1 is expressed in human colorectal tumors, in particular in groups of aggressively migrating cells); single tumor cells from primary tumors (an event called tumor budding), which represents a negative prognostic factor; and in circulating tumor cells as either single cells or aggregates (that are referred to as ‘emboli’ or ‘microemboli’). Here, NLGN1 is linked to colorectal neoplasm.