Eph/ephrin signaling is exceptionally complicated because of its bidirectional nature (with Ephs and ephrins interacting “in trans” from two different cells), and as a consequence Eph/ephrin have been shown to coordinate a plethora of tumor-related processes from angiogenesis, inflammation, vascular infiltration, and metastasis to tumor immunity [175,176,177]. Here, EPHA1 is linked to neoplasm.