Interestingly, the above predominance of senescent subpopulations in SLE patients was even more prominent in female patients and differences of the CD19IgD-CD27- cell count between SLE, ESKD-HD patients, and HC were significant, 10.64 (0.93–122.91), 7 (3–35), 19 (7–62) cells/μL, respectively, p = 0.003. Here, CD27 is linked to systemic lupus erythematosus.