The count of CM (CD4CD45RA-CD57+), EM (CD4CD45RA-CD57−), and EMRA (CD4CD45RA+CD57−) CD4+ subpopulations were significantly reduced in SLE patients compared to the healthy control group; p = 0.046, p = 0.002, p = 0.027, respectively. The gene discussed is CD4; the disease is systemic lupus erythematosus.