Very interestingly, most studies regarding immunosenescence in SLE revealed an upregulation of advanced differentiated lymphocytes, for instance, CD28null-angiogenic T cells, CD4+KLRG1+, CD8+KLRG1+, and CD8+CD57+ cells, with no significant changes in naïve populations. Here, B3GAT1 is linked to systemic lupus erythematosus.