More specifically, compared to HC, SLE patients had reduced percentage of naïve, IgD+CD27−, 62 (24)% vs. 54 (41)%, IgM memory, IgD+CD27+ 8.9 (9)% vs. 4.4 (6)%, respectively, and increased percentages of switched memory, IgD-CD27+ 17.2 (14)% vs. 19 (20)% and late differentiated B lymphocytes, IgD-CD27− 8.1 (10)% vs. 11.7 (10)%, respectively. This evidence concerns the gene CD27 and systemic lupus erythematosus.