Furthermore, the increased rate of migration, along with a change in the shape of resistant cells [6], numerous changes in the level of proteins that form and regulate the cytoskeleton (Figure 2, Supplementary Table S1), and an increased number of proteins involved in tumor progression (e.g., EGFR, CD44, STAT3, RELA in Supplementary Table S5) may suggest that resistance to PDT in CAL-39 cells increased at least partially through EMT. This evidence concerns the gene CD44 and neoplasm.