On the other hand, as IL-10 is thought to be a key suppressor of the immune response [42], the observed upregulation of this cytokine in both timepoints in our study might also be a compensatory protective mechanism in response to the overexpression of IL6 and IL18, i.e., both cytokines with pro-inflammatory actions found in our hyperglycemic GDM women during and after pregnancy, and this possibility needs to be addressed by future studies. This evidence concerns the gene IL18 and gestational diabetes.