The IL8 expression profile showed a U-shape, with a significant decrease in the GDM group relative to the NGT group (FC 0.57, p = 0.0004) and a significant increase at postpartum follow-up compared to the GDM group (FC = 1.86, p = 0.0006), but achieved a level similar to that of the NGT group (p > 0.05). The gene discussed is CXCL8; the disease is gestational diabetes.