In conclusion, our data demonstrate a differential transcriptional response of the set of inflammation-related genes in leukocytes of the pregnancies with GDM at the time of GDM diagnosis and 1-year postpartum, with GDM-specific downregulation of IL8 and pGDM-specific upregulation of IL13 and RELA accompanied by upregulation of IL6, IL10, and IL18 in both groups. This evidence concerns the gene IL6 and gestational diabetes.