CCND1 and osteosarcoma: Indeed, TQ was shown to induce G1 arrest in HCT 116 human colorectal carcinoma cells through the regulation of p53 [55], acute lymphoblastic leukemia Jurkat cell lines via a p73-dependent pathway as evident by p73 siRNA [83], LNCaP prostatic cancer cells by an increase in p21 and p27 and a decrease in E2 transcription factor [59], SP-1 mouse papilloma carcinoma cells through an increase in p16 and decrease in cyclin D1 [58], COS31 canine osteosarcoma cell lines [54], and MDA-MB-468 and MDA-MB-231 triple-negative breast carcinoma cells with mutant p53 [109].