Contrastingly, human U373MG glioblastoma cells transfected to express TNFα exhibited reduced P-gp protein expression, in a manner inversely proportional to the amount of TNFα secreted, which was accompanied by reductions in rhodamine 123 transport and increased chemosensitivity to vincristine and doxorubicin [69]. The gene discussed is PGP; the disease is glioblastoma.