Interestingly, exposure of mouse brain capillaries to human Aβ40 peptides enhances Nedd4 protein expression and concomitantly decreases P-gp protein expression [101], thus paving the potential for modulation of NEDD4-1 as a strategy to restore P-gp expression and activity in Alzheimer’s disease. Here, NEDD4 is linked to early-onset autosomal dominant Alzheimer disease.