As mentioned in the Introduction, there is no doubt that PCOS is associated with significant elevations of multiple markers of inflammation, including CRP, hs-CRP, IL-18, IL-34, TNF-α, TGFβ, IL-6, MCP-1, C3, and MIP-1α [14,16,116,117]. The gene discussed is IL18; the disease is polycystic ovary syndrome.