There are also markers of endothelial dysfunction/damage in PCOS, including asymmetric dimethylarginine (ADMA), CRP, homocysteine, plasminogen activator inhibitor-I (PAI-I), PAI-I activity, and vascular endothelial growth factors (VEGFs) [14,27,28]. The gene discussed is CRP; the disease is polycystic ovary syndrome.