Thus, any epigenetic regulation that leads to a decrease in the expression of the CYP19A1 (aromatase) gene in granulosa cells or a decrease in the relative expression rate of GC aromatase, as well as producing upregulation of AR and increased activity of the key enzymes essential for androgen biosynthesis in thecal cells (i.e., CYP11A1, CYP17, and HSD3B2), should be considered in the context of inflammation in PCOS [211,215,216,217] (Figure 3). This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.