In addition to the inflammatory response due to disrupted mitochondrial biogenesis, some recent studies demonstrated that involvement of mTOR signaling or the PI3K/AKT/mTOR pathway is an important pathophysiological basis of PCOS because overexpression of the mTOR pathway can impair the interaction of cumulus cells, lead to IR, and directly affect follicle growth [111]. This evidence concerns the gene MTOR and polycystic ovary syndrome.