For example, gene ontology and pathway analysis showed that dysregulated lncRNAs in GCs in PCOS with hyperandrogenism have a regulatory role in mitochondrial function by interacting with transcription factors such as yin-yang 1 (YY1) and SIX homeobox 5 (SIX5) [109]. The gene discussed is SIX5; the disease is polycystic ovary syndrome.