NFKB1 and muscular dystrophy: In addition, we found that ONX-0914 negatively modulated interleukin-6 (IL-6), the master regulator of the inflammatory machinery, and the protein kinase C (PKC)-α, which is known to modulate pathways involving NF-κB, NO and MAPKs, and to coordinate heart function and contraction/relaxation of myocardium in muscular dystrophies (Figure 4B).