This category comprises several different types of amyloid-unrelated pathologies such as primary age–related tauopathy (PART) [26], hippocampal sclerosis [27,28,29], TAR DNA binding protein (TDP)-43 pathology [30,31], argyrophilic grain disease (AGD) [32,33], and accelerated aging [34]. This evidence concerns the gene TARDBP and argyrophilic grain disease.