For example, depletion, by antisense oligonucleotides, of TDP-43 from adult mouse brain results in RNA mis-splicing; in particular, TDP-43 depletion affects the production of a variety of transcripts, among which those for FUS and Progranulin, which also have a specific role in ALS [335]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.