TARDBP and neurodegenerative disease: Notably, while studying the interaction between HnRNP-A2 and TDP-43, a mechanism of reciprocal regulation through IDRs was evidenced: in some neurodegenerative diseases (see Section 4), TDP-43 shows a transition from an alfa-helix to a beta-sheet structure, which favors its aggregation, and it was found that an increase in the disordered conformation of HnRNP-A2 is directly related to the increase in the beta-sheet structure in TDP-43 [154].