Accordingly, Tebaldi et al. showed that genes associated with MN diseases, such as ALS and spinal muscular atrophy (SMA), were enriched among HuD targets and that HuD overexpression in NSC-34 cells (a mouse hybrid line between MNs and neuroblastoma) increases their translation [63]. This evidence concerns the gene ELAVL4 and spinal muscular atrophy.