Our search also identified a family of molecules associated with lipid metabolism, which includes the very low-density lipoprotein receptor (VLDR), the low-density lipoprotein receptor (LDLR), and apolipoproteins A-I and -II, C-I and E as well as B. Dysregulated lipid metabolism is known to play an important role in retinal pathology [70] including mediating effects of poor nutrition, which is a modifiable AMD risk factor. The gene discussed is LDLR; the disease is age-related macular degeneration.