Consistent with an oncogenic role for PSMD3 in FLT3-mutated AML, shRNA-mediated knockdown of PSMD3 impaired survival of all three cell lines in colony formation assays in vitro, in the presence and absence of the FLT3 TKI, quizartinib (also known as AC220, Figure 2C,D,left, Supplementary Figure S1B, left). Here, PSMD3 is linked to acute myeloid leukemia.