FLT3 and acute myeloid leukemia: To assess the role of PSMD3 in AML, we transduced the FLT3-mutated AML cell lines, MOLM-13, MOLM-14, and MV4-11 with doxycycline-inducible shPSMD3, and confirmed PSMD3 knockdown at the mRNA and protein level in the presence of doxycycline (Figure 2A,B, Supplementary Figure S1A).