KITLG and in situ carcinoma: IgG SCF to serum ratio significantly differed across groups (F = 3.523, p = 0.023) and this difference was attributed to patients with CIS who exhibited lower IgG CSF to serum ratio compared to patients with RRMS cluster 1 (0.64 ± 0.04 vs. 1.05 ± 0.14, p = 0.017).