In contrast, RSK4 was identified as a tumour suppressor in other malignancies, such as colorectal and gastric cancers, as well as acute myeloid leukaemia (AML), where its overexpression induced cell cycle arrest, inhibited cell invasion and metastasis, and was associated with better patient survival [23,24,25,26,27]. This evidence concerns the gene RPS6KA6 and neoplasm.