The analysis of the whole-tumor tissue had given researchers the idea that acinar cells could be the origin of human pancreatic neoplasia but with the help of LCM, PanIN lesions, acinar-ductal metaplasia lesions, stromal cells, and acinar cells were isolated and closely studied for KRAS mutation (LigAmp technique) to disapprove this hypothesis [57]. The gene discussed is KRAS; the disease is neoplasm.