Likewise, other findings such as the silencing of CDKN1C by an epigenetic mechanism [48], the role of FXYD3 in cell proliferation [67], and the association of the Sox4/Ezh2 and miR-335 with the epigenetic mechanism of Sox4 expression, which in turn stimulated EMT pathway [68], were possible on cell lines, xenografts, and PDAC samples using LCM as it aided in the selection of tumor and healthy tissue. This evidence concerns the gene SOX4 and neoplasm.