IBSP and pachyonychia congenita: Bone Sialoprotein (BSP) is a member of the SIBLING family of proteins and was studied using LCM along with qPCR, DNA microarray, immunoblotting, radio-immunoassays, IHC, cell-growth, invasion, scattering, and adhesion assays on chronic pancreatitis, PDAC, and PC cell lines, to mark its importance in cancer growth, and metastasis (Figure 3) [78].