Notably, SQSTM1 is a causative gene in patients with ALS [59] and FTD [60,61], and its protein p62 is found in the pathological protein inclusion in patients with ALS/FTD [62,63,64] and in SGs colocalized with the autophagosome marker LC3-II [35]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.