NLRP3 and familial cold autoinflammatory syndrome: The NLRP3 inflammasome is the best known inflammasome due to mutations on its exon 3 responsible for the appearance of serious inflammatory diseases including severe chronic infantile neurological cutaneous and articular syndrome; familial cold autoinflammatory syndrome (FCAS), also known familial cold urticaria; Muckle–Wells syndrome, and acute pancreatitis.