The MIR17HG gene encodes a cluster of six miRNAs that have been shown to increase sensitivity to palbociclib in atypical teratoid rhabdoid tumors (ATRTs), a fatal pediatric malignancy of the central neural system caused by SMARCB1 deficiency [76,77]. The gene discussed is SMARCB1; the disease is atypical teratoid rhabdoid tumor.