The DARC serves as a receptor for several chemokines, such as melanoma growth-stimulating activity (MGSA) and interleukin (IL)-8; these can inhibit P. vivax and P. knowlesi binding to DBL domains and Duffy-positive (DARC-positive) erythrocytes, suggesting that the binding sites on the DARC used by chemokines and parasite proteins overlap [2,26]. This evidence concerns the gene ACKR1 and melanoma.