The expression of inflammasome components (cleaved IL-1β, cleaved-CASP1, ASC, and NLRP3) was increased in COVID-19 variants and overexpressed in COVID-19/B.1.1.7 patients (Figure 2; p < 0.05 compared with COVID-19/B.1 variant) as indicates the immunohistochemical composite score (Figure 2B). This evidence concerns the gene IL1B and COVID-19.