CASP1 and COVID-19: The expression of inflammasome components (cleaved IL-1β, cleaved-CASP1, ASC, and NLRP3) was increased in COVID-19 variants and overexpressed in COVID-19/B.1.1.7 patients (Figure 2; p < 0.05 compared with COVID-19/B.1 variant) as indicates the immunohistochemical composite score (Figure 2B).