NOX4 and COVID-19: In this work we detected elevated levels of Nrf2 in COVID-19 patients compared with non-COVID-19 patients and observed that SARS-CoV-2 mosaic (S-E-M) protein increases the expression of both Nrf2 and NOX4 in macrophages and bronchial epithelial cells in vitro, through the activation of TLR2 receptor.