SH3GLB2 and Parkinson disease: The second important finding is that as an inducer of PD, neurotoxin MPP+ rapidly increases WWOX phosphorylation at Tyr33 [29] and upregulates the expression of TPC6AΔ, followed by TIAF1, SH3GLB2, Aβ, and tau in neuroblastoma SK-N-SH cells.