Important signaling pathways are mediated by hedgehog (HH), Notch, wigless (Wnt), hippo (Salvador-Warts-Hippo), JAK/STAT, TRPV4, cAMP/cGMP, mTOR and platelet-derived growth factor (PDGF) for intercellular communications between cancer cells [39,40,64,65]. Here, TRPV4 is linked to cancer.