The present study also investigated morphological and adaptive changes occurring after CCI of the sciatic nerve and peripheral nerve lesion by comparing the impact of MTF therapy and different expression of large myelinated A-β fiber neurons (e.g., NF200), peripheral myelin protein 22 (PMP22), myelin protein zero (P0), Schwann cells proliferation (Cdc2) and macrophages (CD11b). Here, PMP22 is linked to peripheral nerve lesion.