B3GAT2 and hyperandrogenism: Additionally, a strong correlation between elevated BPA exposure and hyperandrogenism in the setting of polycystic ovary syndrome was described by various authors [16,22,31], although it needs to be acknowledged that elevated androgen levels down-regulate the activity of UDP-glucuronosyltransferase, inducing a decrease in BPA clearance and an increase in its urine and blood concentration [70].