Its core pathway is an important tumor suppressor, which is composed of mammalian sterile 20-like kinase 1/2, MST1/2, salvador homologue 1(SAV1) containing WW domain, large tumor suppressor 1/2 (SAV1), LATS1/2) and 1 MOB kinase activator (MOB kinase activator 1, MOB1) A. MOB1B constitutes the core of the kinase box, and when the Hippo-YAP/TAZ pathway is activated, MST1/2, with the help of SAV1, Phosphorylated MOB1 and LATS1/2, enhances the auxiliary activation of MOB1 on LATS1/2. This evidence concerns the gene MST1 and neoplasm.