Of the clinical and laboratory parameters associated with severe AF-TR in univariate analysis (Table 3), the RAD (HR 1.11, p = 0.005), sPAP (HR 1.20, p = 0.015) and NT-proBNP (HR 2.37, p = 0.026) were independent predictors for the presence of severe valvular dysfunction in multivariable analysis (Table 4). The gene discussed is PDZK1IP1; the disease is atrial fibrillation.