In a subgroup analysis of 5387 patients on HD from the Dialysis Outcomes and Practice Patterns Study (DOPPS) phases 1–4, naïve of CKD–MBD treatment, PTH levels < 50 pg/mL were associated with 25% higher mortality in comparison to PTH levels between 150 and 300 pg/mL [77]. The gene discussed is PTH; the disease is Marchiafava-Bignami disease.