Despite the fact that NT-proBNP levels are predictors for adverse long-term outcomes in patients with known heart failure or pulmonary arterial hypertension [23], Bassan et al. showed that BNP measured at hospital admission in patients with non ST elevation acute coronary syndrome is a strong, independent predictor of very long-term all-cause mortality [24]. The gene discussed is NPPB; the disease is acute coronary syndrome.