The potential predictive ability of the preoperative NT-proBNP level for the occurrence of postoperative SCA and death in patients after SCA demonstrated in the study may indicate that the overloaded and damaged myocardium in a patient undergoing heart valve surgery is particularly sensitive to the non-physiological conditions prevailing in the perioperative period, which may cause serious hemodynamic disturbances in the postoperative period, and consequently, may be the cause of death. The gene discussed is NPPB; the disease is autosomal dominant cerebellar ataxia.