To reduce levodopa-related side effects (e.g., nausea, vomiting, orthostatic hypotension) resulting from the conversion of levodopa to dopamine outside the central nervous system via DOPA decarboxylase, levodopa is routinely given in combination with peripheral DOPA decarboxylase inhibitors (DCI) such as carbidopa or benserazide [4,5]. Here, DDC is linked to orthostatic hypotension.