Taken together, since individuals with higher WrC levels have potentially lower ratios of adiponectin-leptin, with the lower protective role of adiponectin and greater destructive role of leptin on bone metabolism, it can be speculated that individuals with high levels of WrC are more susceptible to osteoporosis, and as a consequence, osteoporosis-related fractures. Here, ADIPOQ is linked to osteoporosis.