AGT and hypertensive disorder: They also explained that the diverse mechanisms of cortisol had indirect effects on such factors as hypertension [104], noradrenalin and angiotensin II [105], and the local RAA system [106], as well as direct effects, such as stimulation of cell cycle activity in cardiomyocytes leading to proliferation [107] and accelerating of cardiomyocyte hypertrophy by expression of angiotensinogen mRNA [108].