Diagnostic criteria for CVID, according to the European Society for Immunodeficiencies (ESID), include a decrease in IgG (at least two standard deviations below the mean for age) and a marked decrease in at least one of the isotypes IgM or IgA, an impaired antibody production to vaccination or low percentage of switched memory B cells (<70% of age-related normal value), clinical manifestations of recurrent infections, autoimmune diseases or lymphoproliferation, the onset of clinical immunodeficiency at more than two years of age and the exclusion of other causes of hypogammaglobulinemia [5]. This evidence concerns the gene CD40LG and immune system disorder.