Although not considered as diagnostic criteria so far, some non-criteria aPLA (including anti-phosphatidylserine/prothrombin, anti-phosphatidylserine, anti-phosphatidylethanolamine and anti-annexin V antibodies) have shown the capacity to increase the diagnostic accuracy of APS and may become important in the future [42]. The gene discussed is ANXA5; the disease is autoimmune polyendocrinopathy.