AQP4 and ischemic stroke: For example, in non-reperfusion ischemic (via occluding medial cerebral arteries) rodent models, inhibition of AQP4 with TGN-020 has shown a decrease in glial scarring, apoptosis and cerebral edema [79,137], thus implicating the potential of such interventions in modulating clinical outcomes of pathologies such as ischemic stroke [46].