One study found that SOD1G93A AQP4−/− ALS mouse models had improved BBB permeability compared to AQP4+ SOD1G93A mouse models, with reduced hemosiderin deposition and immunoglobulin leakage; however, AQP4− SOD1G93A mice showed an earlier age of disease onset and shorter lifespan compared to AQP4+ SOD1G93A mice [99]. The gene discussed is AQP4; the disease is amyotrophic lateral sclerosis.