PPARG and polycystic ovary syndrome: Interestingly, dehydroepiandrosterone (DHEA)-induced PCOS in rats was shown to respond to omega-6 fatty acid (γ-linolenic acid (GLA)) treatment that led to a significant decrease in IL-33 levels in the rat’s ovaries, hence, implicating GLA’s potential use for likely human-related treatments for inflammatory responses in PCOS via the PPAR-γ pathway [60].