Tumor cells are able to develop resistance to apoptosis by overexpressing BCL-2 and other anti-apoptosis molecules, or immune inhibitory receptor ligands such as programmed death ligand 1 (PD-L1), Fas ligand and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) [28]. The gene discussed is TNFSF10; the disease is neoplasm.