For instance, RNA sequencing of TEVs derived from chronic lymphocytic leukemia (CLL) revealed a high enrichment of non-coding Y RNA hY4 which transfer increased the release of cytokines [e.g., C-C motif chemokine ligand 2 (CCL2), CCL4, IL-6] and the expression of PDL1 expression in circulating monocytes via TLR7 signaling [49]. Here, TLR7 is linked to B-cell chronic lymphocytic leukemia.