In the univariable analysis, high education level, history of CHD, hypertension, drinking alcohol, drinking tea, high BMI, central obesity, visceral fat obesity, hyper-TG, hyper-TC, hypo-HDL-C, abnormal ALT, and abnormal AST were all significantly associated with hyperuricemia, while smoking was protective. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.