Recent studies have demonstrated that mechanical loading associated with high-intensity interval training (HIIT) may improve bone status and atherosclerosis parameters (i.e., carotid intima-media thickness (cIMT)) through a decrease in the serum levels of Wnt signaling inhibitors, such as Dkk-1 and sclerostin, thus decreasing cardiovascular risk [33]. Here, SOST is linked to atherosclerosis.