HSPA5 and obesity due to melanocortin 4 receptor deficiency: Shown by drug affinity responsive target stability (DARTS) and surface plasmon resonance (SPR) results, epigallocatechin gallate (EGCG), dihydromyricetin (DHM) and berberine, the major active ingredient of flavonoids, induce white fat tissue browning but prevent adipogenesis or obesity via directly binding to GRP78 [23].