A literature search with the keywords “GRP78” or “BiP/HSPA5” gave more than 20,000 publications in the Web of Science, PubMed, ACS, Elsevier and Wiley databases, but few using the keywords of “obesity” and “GRP78” or “BiP/HSPA5” (accessed on 15 September 2022). This evidence concerns the gene HSPA5 and obesity due to melanocortin 4 receptor deficiency.