Shown by drug affinity responsive target stability (DARTS) and surface plasmon resonance (SPR) results, epigallocatechin gallate (EGCG), dihydromyricetin (DHM) and berberine, the major active ingredient of flavonoids, induce white fat tissue browning but prevent adipogenesis or obesity via directly binding to GRP78 [23]. Here, HSPA5 is linked to obesity disorder.