For liver tissue, relative to SKBR3 bearing tumor control, BPAF at 20 mg/kg bw/day significantly up-regulated the gene expression of four genes (MAPK3, MAPK6, EBP1, CCND1) (Figure 4A), whereas the mRNA relative levels of the other 15 genes had no a statistical difference. The gene discussed is CCND1; the disease is neoplasm.