At 100 mg/kg bw/day, BPAF resulted in the significant upregulation in gene expression of seven targets (GPER1, JNK, Akt, Fos, FOXO1, PDZK1, SRF), while the gene expression of the other 12 targets were not significantly changed compared to the SK-BR-3 bearing tumor control. The gene discussed is FOXO1; the disease is neoplasm.