When the nude mice were treated with 100 mg/kg bw/day BPAF, the gene expression of 11 targets (GPER1, ESR1, EGFR, MAPK6, JNK, Akt, Myc, EBP1, FKBP1A, PGR, CCND1) were significantly up-regulated and the mRNA levels of Fos were significantly down-regulated, while the mRNA levels of the other seven genes had no the significant change relative to SK-BR-3 bearing tumor control. This evidence concerns the gene FOS and neoplasm.