For ovarian tissue, compared with SK-BR-3 bearing tumor control, the mRNA level of only MAPK3 in ovarian tissue was significantly up-regulated when the exposure dose of BPAF was 20 mg/kg bw/day, and the gene expression of five targets (MAPK1, TFF1, Fos, FOXO1, CCND1) were significantly down-regulated (Figure 3A). The gene discussed is FOS; the disease is neoplasm.