CLOCK and metabolic syndrome: When considering the methylation status of the single clock genes, whereas at T0, there were no significant differences in methylation level of any clock genes, the BWRP induced a significant hypermethylation only of the per3 gene in the group with metabolic syndrome (p of interaction term time × metabolic syndrome 0.0095; in the group with metabolic syndrome, T0 vs. T1: 82.95 ± 0.89 vs. 86.19 ± 0.82, p 0.0046) (Figure 2).