CRY2 and metabolic syndrome: This is particularly evident when considering the increasing number of associations (statistically significant or close the statistical significance) of the methylation level of clock genes with cardiometabolic outcomes at the end of the BWRP, including FM (a surrogate of WC) (cry2 and per1), HDL-C (cry1), SBP (per2), DBP (per2) and TG (per2), which (non-surprisingly) represent the IDF criteria for metabolic syndrome [37] and (surprisingly) were not present before BWRP administration (i.e., T0).