Besides MAFLD and coincidental metabolic abnormalities, we also examined three major fatty liver disease-related genetic variants [18], which have been associated with steatosis/fibrosis/cirrhosis and HCC risk (mainly in Caucasians, especially the UK biobank cohort [27,28,29]), and found that the PNPLA3 rs738409 GG and MBOAT7 rs641738 TT homozygous missense variants were also associated with an increased risk of HCC in CHB. Here, PNPLA3 is linked to fatty liver disease.