CLL cells exhibit a dysregulated PKC isoform expression profile: upregulation of PKCβII, PKCε, PKCζ and downregulation of PKCα and PKCβI compared to normal B cells, with the increased levels of PKCβII expression correlating with the poor prognostic outcome for CLL patients [8]. The gene discussed is PRKCA; the disease is B-cell chronic lymphocytic leukemia.