Enza significantly decreased overall c-MycS62 phosphorylation upon BCR-XL; however, coupled with the significant reduction in total c-Myc protein with IB or Enza treatment, this led to a significant increase in pc-MycS62 phosphorylation on the remaining c-Myc in human CLL cells (Figure 6B, Supplementary Figure S6), findings that mirrored trends in PKCα-KR CLL-like cells. This evidence concerns the gene PRKCA and B-cell chronic lymphocytic leukemia.