As it has previously been established that inhibition of BCR-mediated signals with IB can reduce CLL cell migration towards CXCL12 [19], and leukocyte migration was the fourth most dysregulated pathway in PKCα-KR cells, the migration capacity of MIEV and PKCα-KR CLL-like cells was tested in the presence of IB or Enza treatment. Here, CXCL12 is linked to B-cell chronic lymphocytic leukemia.