PRKCA and B-cell chronic lymphocytic leukemia: To investigate global gene expression profiles in the PKCα-KR CLL mouse model within the timeline of PKCβII upregulation, microarrays were performed comparing MIEV- and PKCα-KR-transduced cells at the late stage of B cell transformation (post d17 of co-culture after retroviral transduction with MIEV- and PKCα-KR-constructs at d0 [12]).