Taking into consideration that preceding similar results have been published in pNET [40] and colorectal cancer [19], but not in BL PDAC, our results suggested for the first time that a higher tumor infiltration of both CD4+ and CD8+ cell subtypes was associated with higher PFS, with a substantial increase in OS and cancer-associated survival in case of high CD8+ lymphocytes. This evidence concerns the gene CD4 and neoplasm.