Finally, and only focusing on the BL cohort, we were able to develop a score based on circulating IL-10, MDC, MIF, and eotaxin-3 levels that showed a meaningful statistically significant prognostic role for PFS (HR = 4.07; 95% CI: 1.48–1.15; p = 0.006). This evidence concerns the gene MIF and Burkitt lymphoma.