The induction of Mll::Af9 in primitive progenitor cells using Lmo2-Cre gives rise to AML, but not when Mll::Af9 is induced in other cell types, such as T-cells, or following the induction of different Mll::FPs, such as Mll::Af4 [46]. Here, KMT2A is linked to acute myeloid leukemia.