In addition to these direct interactions between PDCD10 and other molecules, some pathways such as DLL4-Notch signaling, EphB4 signaling, and even the gut-brain axis were also reported to be regulated by PDCD10 in CCM [66,75,76], though how PDCD10 regulates these pathways needs further exploration. The gene discussed is PDCD10; the disease is cerebral cavernous malformation.